Product Details
Features and Advantages
- Native Conformation: Native sequences, tag-free and natural function.
- Reliable Activity: Biological activity calibrated against WHO/NIBSC standards.
- Stringent Quality Control: Protein content, purity, and cell-based bioactivity testing for each batch.
- Lowest Endotoxin level (<0.01 EU/ug).
- Safety Assurance: Sterile filtration through 0.2 μm membrane.
- AOF: Animal origin-free raw materials throughout the production process.
Source
Monoclonal Anti-Human 4-1BB Antibody, Mouse IgG1, Research Grade (41B-CH25GN) is a chimeric monoclonal antibody recombinantly produced from CHO cells, which combines the variable region of a human monoclonal antibody with mouse IgG1 constant domain.
Isotype
Mouse IgG1 | Mouse Kappa
Conjugate
Unconjugated
Specificity
This product is a specific antibody specifically reacts with 4-1BB.
Endotoxin
Less than 0.002 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
Formulation
Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Shipping
This product is supplied and shipped with dry ice, please inquire the shipping cost.
Storage
For long term storage, the product should be stored at liquid state at -20°C or below.
This product is stable after storage at:
- -20°C or below for 24 months under sterile conditions;
- 2-8°C for 12 months after thaw if within expiry date.
ACRO Quality Management System
Quality Description
ACRO's Research-grade products are suitable for a wide range of cell culture applications, particularly for research use in academic institutions. These products are sterilized by filtration, followed by lyophilization where applicable. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. Biological activity is calibrated against WHO/NIBSC standards when available.
ACRO's Premium-grade (Pre-GMP) products are characterized by their high quality and enhanced safety profiles, making them ideal for early-stage discovery and manufacturing processes in cell therapy companies. A key advantage is their seamless transition to corresponding GMP-grade versions. Biological activity is calibrated against WHO/NIBSC standards when available. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. In addition, rigorous testing is conducted to ensure the absence of mycoplasma, HCD, and HCP, thereby guaranteeing product safety.
Customers Also Viewed
Performance Data
SDS-PAGE

Monoclonal Anti-Human 4-1BB Antibody, Mouse IgG1, Research Grade on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS

The purity of Monoclonal Anti-Human 4-1BB Antibody, Mouse IgG1, Research Grade (Cat. No. 41B-CH25GN) is more than 95% and the molecular weight of this protein is around 135-165 kDa verified by SEC-MALS.
Report
Bioactivity-CELL BASE

Monoclonal Anti-Human 4-1BB Antibody, Mouse IgG1, Research Grade (Cat. No. 41B-CH25GN) stimulates the secretion of IL-8 by HT1080 human CD137 cell line. The typical EC50 for this effect is 35.62 ng/mL (QC tested).
Protocol
Bioactivity-ELISA

Immobilized Human 4-1BB, His Tag (Cat. No. 41B-H52Hc) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human 4-1BB Antibody, Mouse IgG1, premium grade (Cat. No. 41B-CH25GN) with a linear range of 0.1-2 ng/mL (QC tested).
Protocol
Customer Reviews Writing Reviews

Background
4-1BB activation enhances CD8 T cell and NK cell mediated anti-tumor immunity . It also contributes to the development of inflammation in high fat diet-induced metabolic syndrome . Soluble forms of 4-1BB and 4-1BB Ligand circulate at elevated levels in the serum of rheumatoid arthritis and hematologic cancer patients, respectively .
Recent Advances
- English Name:
Tumor necrosis factor receptor superfamily member 9
- Category:
- Approved Drugs:
0 Details
- Drugs in Clinical Trials:
77 Details
- Highest Development Stage:
Phase 3 Clinical
전화
글로벌: +1 800-810-0816 (무료)
아시아태평양: +86 400-682-2521


















