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Home PageAll MoleculesNOTCH1
NOTCH1
NOTCH1 Overview
| English Name | Neurogenic locus notch homolog protein 1 | Approved Drugs | 0 |
| Drugs in Clinical Trials | 1 | Target Synonym | Notch Receptor 1，EC 2.1.2.11，Translocation-associated notch protein TAN-1，NEXT，NICD，hN1，NOTCH1，Notch 1，TAN1，Notch (Drosophila) Homolog 1 (Translocation-Associated)，Notch Homolog 1， Translocation-Associated (Drosophila)，Notch Homolog 1， Translocation-Associated，AOVD1，AOS5，Receptor， Notch1，EC 3.4.21.68，Neurogenic locus notch homolog protein 1 |
| Highest Development Stage | Phase 1 Clinical | ||
| English Name | Neurogenic locus notch homolog protein 1 |
| Target Synonym | Notch Receptor 1，EC 2.1.2.11，Translocation-associated notch protein TAN-1，NEXT，NICD，hN1，NOTCH1，Notch 1，TAN1，Notch (Drosophila) Homolog 1 (Translocation-Associated)，Notch Homolog 1， Translocation-Associated (Drosophila)，Notch Homolog 1， Translocation-Associated，AOVD1，AOS5，Receptor， Notch1，EC 3.4.21.68，Neurogenic locus notch homolog protein 1 |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 1 |
| Highest Development Stage | Phase 1 Clinical |
NOTCH1 Product List
- Product Category
Protein (4)
- Product Status
Launched (4)
- Species
Mouse (1)Human (3)
- Tag
His Tag (2)Fc Tag (2)
- Conjugate
Unconjugated (3)Biotin-labeled (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
HOT NO1-H52H3 |  Human | HEK293 | Human NOTCH1 Protein, His Tag, premium grade |  |  |  |
NO1-H5255 | Human | HEK293 | Human NOTCH1 Protein, Fc Tag (MALS verified) |  | | |
NO1-H8253 | Human | HEK293 | Biotinylated Human NOTCH1 Protein, Fc Tag, ultra sensitivity (primary amine labeling) |  | | |
NO1-M52H8 |  Mouse | HEK293 | Mouse NOTCH1 Protein, His Tag |  | | |
Total: 4
- 1
NOTCH1 Background
NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.
NOTCH1 Synonyms
NOTCH1,Notch 1,hN1,TAN1
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Crenigacestat | JSMD-194; LY-3039478; BMS-986405 | Phase 2 Clinical | Eli Lilly And Company | Breast Neoplasms; Neoplasm Metastasis; Leukemia, T-Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Hepatocellular; Lymphoma; Lymphoma, T-Cell; Leukemia, B-Cell; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours; Cholangiocarcinoma; Sarcoma; Multiple Myeloma; Carcinoma, Adenoid Cystic; Colonic Neoplasms; Triple Negative Breast Neoplasms; Leiomyosarcoma; Lymphoma, B-Cell | Details |
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