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Menu
Home PageAll MoleculesComplement C1s
Complement C1s
Complement C1s Overview
| English Name | Complement C1s | Approved Drugs | 4 |
| Drugs in Clinical Trials | 5 | Target Synonym | EC:3.4.21.42，EC 3.4.21，C1 esterase，Complement component 1 subcomponent s，C1S，Complement C1s，Complement Component 1， S Subcomponent，Basic Proline-Rich Peptide IB-1，Complement C1s Subcomponent，EC 3.4.21.42，EDSPD2 |
| Highest Development Stage | Approved | ||
| English Name | Complement C1s |
| Target Synonym | EC:3.4.21.42，EC 3.4.21，C1 esterase，Complement component 1 subcomponent s，C1S，Complement C1s，Complement Component 1， S Subcomponent，Basic Proline-Rich Peptide IB-1，Complement C1s Subcomponent，EC 3.4.21.42，EDSPD2 |
| Approved Drugs | 4 |
| Drugs in Clinical Trials | 5 |
| Highest Development Stage | Approved |
Complement C1s Product List
- Product Category
Protein (1)
- Product Status
Launched (1)
- Species
Human (1)
- Tag
His Tag (1)
- Conjugate
Unconjugated (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
COS-H52H3 |  Human | HEK293 | Human Complement C1s Protein, His Tag (MALS verified) |  |  |
Total: 1
- 1
Complement C1s Background
This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency.
Complement C1s Synonyms
EDSPD2
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Complement-C1 inhibitor protein (Octapharma) | Phase 3 Clinical | Octapharma | Angioedemas, Hereditary | Details | |
| Riliprubart | BIVV-020; SAR-445088; TNT-020 | Phase 3 Clinical | True North Therapeutics | Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Purpura, Thrombocytopenic, Idiopathic; Polyradiculoneuropathy; Rejection of organ transplantation; Anemia, Hemolytic, Autoimmune; Nervous System Diseases | Details |
| C1 esterase inhibitor (Boya Bio-Pharmaceutical) | Phase 3 Clinical | Boya Bio-Pharmaceutical Group Co Ltd | Angioedemas, Hereditary | Details | |
| DNTH-103 | DNTH-103; DNTH103 | Phase 3 Clinical | Dianthus Therapeutics Inc | Myasthenia Gravis; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Motor Neuron Disease; Autoimmune Diseases | Details |
| C1 esterase inhibitor (Chengdu Institute of Biological Products) | Phase 1 Clinical | Chengdu Institute Of Biological Products Co Ltd | Angioedemas, Hereditary | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Conestat alfa | rhC1-INH | Approved | Pharming Group Nv | Rhucin, Esterasine, Ruconest | EU | Angioedemas, Hereditary | Pharming Group Nv | 2010-10-28 | Rejection of renal transplantation; Renal Insufficiency; Genetic Diseases, Inborn; Rejection of organ transplantation; Coronavirus Infections; Angioedema; Angioedemas, Hereditary; Non-ST Elevated Myocardial Infarction | Details |
| Sutimlimab | BIVV-009; TNT-009 | Approved | True North Therapeutics | ENJAYMO | United States | Anemia, Hemolytic, Autoimmune | Bioverativ Therapeutics Inc | 2022-02-04 | Purpura, Thrombocytopenic, Idiopathic; Hemolysis; Anemia, Hemolytic, Autoimmune; Pemphigoid, Bullous; Kidney Failure, Chronic | Details |
| Complement C1 inhibitor protein (Shire ViroPharma) | C1 INH-nf; C1-INH; SHP-616 | Approved | Sanquin Plasma Products Bv | Cinryze, Cetor | United States | Angioedemas, Hereditary | null | 2008-10-10 | Brain Injuries, Traumatic; Rejection of organ transplantation; Angioedemas, Hereditary | Details |
| C1 esterase inhibitor (Human, CSL Behring) | BI-3.012; CSL-830; CSL-842; CE-1145 | Approved | Csl Behring Llc | Berinert, Haegarda, Berinert 2000 | Japan | Angioedemas, Hereditary | Csl Behring Llc | 1990-06-29 | Hereditary Angioedema Types I and II; Angioedemas, Hereditary | Details |
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