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Human Truncated Vitronectin / VTN-N Protein, premium grade

  • GMP version undefined is now available for seamless transition.
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Qty.
VIN-H5117-1mg
¥1575.00
VIN-H5117-5mg
¥7350.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    VTN,V75,VN,Vitronectin,S-protein,Serum-spreading factor

  • 表达区间及表达系统(Source)

    Human Truncated Vitronectin Protein, premium grade (VIN-H5117) is expressed from E. coli cells. It contains AA Val 62 - Leu 478 (Accession # P04004).

    Predicted N-terminus: Met

    It is produced under our rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage. When ready to transition into later clinical phases, we also offer a custom GMP protein service that tailors to your needs. We will work with you to customize and develop a GMP-grade product in accordance with your requests that also meets the requirements for raw and ancillary materials use in cell manufacturing of cell-based therapies.

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Vitronectin Structure

    This protein carries no "tag".

    The protein has a calculated MW of 47.6 kDa.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 0.01 EU per μg by the LAL method.

  • 宿主蛋白残留(Host Cell Protein)

    0.5 ng/µg of protein tested by ELISA.

  • 宿主核酸残留(Host Cell DNA)

    0.02 ng/μg of protein tested by qPCR.

  • 无菌(Sterility)

    Negative

  • 支原体(Mycoplasma)

    Negative.

  • 纯度(Purity)

    95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Supplied as 0.2 μm filtered solution in PBS, 0.15 M Arginine, 250 mM N-Acetyl-L-cysteine, pH7.4 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • 运输(Shipping)

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储(Storage)

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 years under sterile conditions.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 活性(Bioactivity)-SPR

     Vitronectin SPR

    Human ITGAV&ITGB3 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT3-H52E3) immobilized on CM5 Chip can bind Human Truncated Vitronectin Protein, premium grade (Cat. No. VIN-H5117) with an affinity constant of 11.9 nM as determined in a SPR assay (Biacore 8K) (QC tested).

    Protocol

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背景介绍

Vitronectin is also known as S-protein, VN, VTN, V75. Vitronectin, a multifunctional glycoprotein, is involved in coagulation, inhibition of the formation of the membrane attack complex (MAC), cell adhesion and migration, wound healing, and tissue remodeling. The primary cellular source of vitronectin is hepatocytes. Blocking of Hic(a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In addition, Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

前沿进展

 
药物研发进展
  • 英文全称:

    Vitronectin

  • 中文全称:

    玻连蛋白

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    0 详情

  • 最高研发阶段:

    临床前

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